N-支套索冠醚异羟肟酸的合成及其钴(II)配合物的氧加合性能

由乙二胺四乙酸二酐和多缩乙二醇出发,合成了一系列具有N-支套索冠醚结构的二异羟肟酸配体(L1H2~L4H2)及其钴(II)配合物(Co L1~Co L4),以IR,1H NMR,MS和元素分析进行结构表征。测定在不同温度下Co L1~Co L4的氧加合常数In KO2和热力学参数ΔH0、ΔS0,研究了氮杂冠醚环的大小对配合物氧加合性能的影响。     

High‐contrast Noninvasive Imaging of Kidney Clearance Kinetics Enabled by Renal Clearable Nanofluorophores

Noninvasive imaging of kidney clearance kinetics (KCK) of renal clearable probes is key to studying unilateral kidney function diseases, but such imaging is highly challenging to achieve with in vivo fluorescence. While this long‐standing challenge is often attributed to the limited light penetration depth, we found that rapid and persistent accumulation of conventional dyes in the skin “shadowed” real fluorescence signals from the kidneys and prevented noninvasive imaging of KCK, which, however, can be addressed with renal clearable nanofluorophores. By integrating near infrared emission with efficient renal clearance and ultralow background interference, the nanofluorophores can increase kidney‐contrast enhancement and imaging‐time window by approximately 50‐ and 1000‐fold over conventional dyes, and significantly minimize deviation between noninvasive and invasive KCK, laying down a foundation for translating in vivo fluorescence imaging in preclinical noninvasive kidney function assessments.     

Glassy carbon electrode modified with gold nanoparticles and hemoglobin in a chitosan matrix for improved pH-switchable sensing of hydrogen peroxide

Hemoglobin (Hb) has been demonstrated to endow electrochemical sensors with pH-switchable response because of the presence of carboxyl and amino groups. Hb was deposited in a chitosan matrix on a glassy carbon electrode (GCE) that was previously coated with clustered gold nanoparticles (Au-NPs) by electrodeposition. The switching behavior is active (“on”) to the negatively charged probe [Fe(CN)₆ ³⁻] at pH 4.0, but inactive (“off”) to the probe at pH 8.0. This switch is fully reversible by simply changing the pH value of the solution and can be applied for pH-controlled reversible electrochemical reduction of H₂O₂ catalyzed by Hb. The modified electrode was tested for its response to the different electroactive probes. The response to these species strongly depends on pH which was cycled between 4 and 8. The effect is also attributed to the presence of pH dependent charges on the surface of the electrode which resulted in either electrostatic attraction or repulsion of the electroactive probes. The presence of Hb, in turn, enhances the pH-controllable response, and the electrodeposited Au-NPs improve the capability of switching. This study reveals the potential of protein based pH-switchable materials and also provides a simple and effective strategy for fabrication of switchable chemical sensors as exemplified in a pH-controllable electrode for hydrogen peroxide.

A pH “on-off” switchable nanobiosensor was fabricated by casting a chitosan-hemoglobin biocomposite onto nano-gold electrode. This composite film exhibits not only excellent pH-responsive on (pH 4.0)-off (pH 8.0) behavior but also excellent pH-tunable on-off bioelectrocatalysis of H₂O₂.

     

聚氰基丙烯酸乙酯空心纳米纤维的制备

通过溶液聚合法制备了具有空心结构的聚氰基丙烯酸乙酯纳米纤维,纤维直径为50~100 nm.研究了3种溶液体系对形成聚氰基丙烯酸乙酯纳米纤维形貌与直径的影响,并探讨了其形成机理.通过调控溶液体系内外环境可得到不同形貌的聚合物纤维,且纤维表面表现出疏水性质.该方法适用于平整且具有粗糙结构的表面.所形成的聚氰基丙烯酸乙酯纳米纤维涂层可用于基底的疏水改性.     

吡喃盐化合物的合成及应用研究进展

吡喃盐是一类具有独特化学反应活性和光物理性质的杂环化合物,在有机合成、生物传感和光电材料等许多领域展现了良好的应用前景.结合本课题组的研究成果,综述了α-非活性吡喃盐和α-活性吡喃盐化合物的合成研究进展,并介绍了一些典型吡喃盐化合物在有机合成、光敏剂、离子液体和荧光传感材料等领域的应用.     

电感耦合等离子体原子发射光谱法(ICP-AES)测定铜磁铁矿中铜、锰、铝、钙、镁、钛和磷的含量

通过样品处理、干扰实验、方法检出限、准确度和精密度实验,确定了最佳实验条件,建立了电感耦合等离子体-原子发射光谱法(ICP-AES)测定铜磁铁矿中铜、锰、铝、钙、镁、钛和磷含量的方法。试料经盐酸、硝酸、氢氟酸、高氯酸分解,用盐酸溶解盐类,过滤,采用电感耦合等离子体原子发射光谱法同时测定滤液中铜、锰、铝、钙、镁、钛和磷的含量。方法检出限为锰、钛和磷小于0.00085%,其它元素小于0.0054%,分析结果与分光光度法、X射线荧光光谱法(XRF)和原子吸收光谱法(AAS)分析结果一致,8个实验室对5个水平样品进行协同实验给出了方法的精密度。